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FACS analysis of human peripheral blood lymphocytes using GTX00598-11 CD3 epsilon antibody [UCHT1] (PerCP-Cy5.5). Solid line : Primary antibody Dashed line : PerCP-Cy5.5 mouse IgG1 isotype control Antibody amount : 0.5 microg
FACS analysis of human peripheral blood lymphocytes using GTX00598-11 CD3 epsilon antibody [UCHT1] (PerCP-Cy5.5). Solid line : Primary antibody Dashed line : PerCP-Cy5.5 mouse IgG1 isotype control Antibody amount : 0.5 microg
FACS analysis of human peripheral blood lymphocytes using GTX00598-11 CD3 epsilon antibody [UCHT1] (PerCP-Cy5.5). Solid line : Primary antibody Dashed line : PerCP-Cy5.5 mouse IgG1 isotype control Antibody amount : 0.5 microg

CD3 epsilon antibody [UCHT1] (PerCP-Cy5.5)

GTX00598-11
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD3E
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD3 epsilon antibody [UCHT1] (PerCP-Cy5.5)
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: 0.5 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    UCHT1
  • Concentration
    0.1 mg/ml
  • Conjugate
    Double Conjugated
  • Gene ID916
  • Target name
    CD3E
  • Target description
    CD3 epsilon subunit of T-cell receptor complex
  • Target synonyms
    CD3epsilon, IMD18, T3E, TCRE, T-cell surface glycoprotein CD3 epsilon chain, CD3-epsilon, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP07766
  • Protein Name
    T-cell surface glycoprotein CD3 epsilon chain
  • Scientific Description
    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

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  • Zhao E, Maj T, Kryczek I, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2016,17(1):95-103. doi: 10.1038/ni.3313
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  • Kap YS, van Meurs M, van Driel N, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009,57(12):1159-67. doi: 10.1369/jhc.2009.954123
    Read this paper
  • Di Carlo E, D'Antuono T, Pompa P, et al. The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Clin Cancer Res. 2009,15(9):2979-87. doi: 10.1158/1078-0432.CCR-08-1951
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  • Imanguli MM, Swaim WD, League SC, et al. Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Blood. 2009,113(15):3620-30. doi: 10.1182/blood-2008-07-168351
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  • Kim MO, Suh HS, Si Q, et al. Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia. J Virol. 2006,80(1):62-72.
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  • Cappione AJ, Pugh-Bernard AE, Anolik JH, et al. Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol. 2004,172(7):4298-307.
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  • Yarbrough WM, Mukherjee R, Escobar GP, et al. Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling. Circulation. 2003,108(14):1753-9.
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  • Kulas DT, Freund GG, Mooney RA. The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling. J Biol Chem. 1996,271(2):755-60.
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