CD40L/CD154/TRAP, Mouse (HEK293, His)

MedChem Express

CD40L/CD154/TRAP, Mouse (HEK293, His)

10

Research Use Only

98.0

CD40 ligand

CD40L (CD154; TRAP) is a ligand to CD40/TNFRSF5, acts function by generating a costimulatory signal that up-regulates IL-4 synthesis [1] . CD40L is specifically expressed on activated CD4+ T-lymphocytes and involves in activation of NF-kappaB/MAPK pathway [2] [3] . CD40L also involves in B cell differentiation, maturation, and apoptosis [4] . CD40L in mouse, cleaved into 2 chains of membrane form (1-260 a.a.) and soluble form (112-260 a.a.) which serves as a ligand for integrins (ITGA5:ITGB1 and ITGAV:ITGB3). CD40L/CD154/TRAP Protein, Mouse (HEK293, His) has a total length of 149 amino acids (M112-L260), is expressed in HEK392 cells with N-terminal 6*His-tag.

-20°C

12352202