CD45RO antibody [UCHL1] (APC)
GTX79857
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman, Primate
TargetPTPRC
Overview
- SupplierGeneTex
- Product NameCD45RO antibody [UCHL1] (APC)
- Delivery Days Customer9
- Application Supplier NoteFACS: 0.25 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDUCHL1
- Concentration0.05 mg/ml
- ConjugateAPC (Allophycocyanin)
- Gene ID5788
- Target namePTPRC
- Target descriptionprotein tyrosine phosphatase receptor type C
- Target synonymsB220, CD45, CD45R, GP180, IMD105, L-CA, LCA, LY5, T200, receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, glycoprotein 180, protein tyrosine phosphatase, receptor type, c polypeptide
- HostMouse
- IsotypeIgG2a
- Protein IDP08575
- Protein NameReceptor-type tyrosine-protein phosphatase C
- Scientific DescriptionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- ReactivityHuman, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
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- Zhao E, Maj T, Kryczek I, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2016,17(1):95-103. doi: 10.1038/ni.3313Read this paper
- Kap YS, van Meurs M, van Driel N, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009,57(12):1159-67. doi: 10.1369/jhc.2009.954123Read this paper
- Di Carlo E, D'Antuono T, Pompa P, et al. The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Clin Cancer Res. 2009,15(9):2979-87. doi: 10.1158/1078-0432.CCR-08-1951Read this paper
- Imanguli MM, Swaim WD, League SC, et al. Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Blood. 2009,113(15):3620-30. doi: 10.1182/blood-2008-07-168351Read this paper
- Kim MO, Suh HS, Si Q, et al. Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia. J Virol. 2006,80(1):62-72.Read this paper
- Cappione AJ, Pugh-Bernard AE, Anolik JH, et al. Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol. 2004,172(7):4298-307.Read this paper
- Kulas DT, Freund GG, Mooney RA. The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling. J Biol Chem. 1996,271(2):755-60.Read this paper