CD46 Polyclonal Antibody
RD70031A
ApplicationsImmunoHistoChemistry
Product group Antibodies
ReactivityMouse, Rat
TargetCD46
Overview
- SupplierReddot Biotech
- Product NameCD46 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration2 mg/ml
- ConjugateUnconjugated
- Gene ID4179
- Target nameCD46
- Target descriptionCD46 molecule
- Target synonymsAHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
- HostRabbit
- IsotypeIgG
- Scientific DescriptionActs as a cofactor for complement factor I,a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- ReactivityMouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203