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CD46(122.2), CF405S conjugate, 0.1mg/mL [26628-22-8]

CD46(122.2), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040175
Biotium
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCD46
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Overview

  • Supplier
    Biotium
  • Product Name
    CD46(122.2), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    122.2
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID4179
  • Target name
    CD46
  • Target description
    CD46 molecule
  • Target synonyms
    AHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP15529
  • Protein Name
    Membrane cofactor protein
  • Scientific Description
    CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203