Overview
- SupplierGeneTex
- Product NameCD73 antibody [N1N3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.28 mg/ml
- IsotypeIgG
- Scientific DescriptionEcto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.[supplied by OMIM]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Age-dependent membrane release and degradation of full-length glycosylphosphatidylinositol-anchored proteins in rats. Mueller GA et al., 2020 Sep, Mech Ageing DevRead more
- Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma. Ma SR et al., 2017 Jun 7, Mol CancerRead more
- CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts. Aoki M et al., 2019 Sep 12, BMC CancerRead more
- Exosomes from TNF-alpha-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss. Nakao Y et al., 2021 Mar 1, Acta BiomaterRead more
- Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells. Casciaro F et al., 2020 Oct, Mech Ageing DevRead more