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FACS analysis of human peripheral blood lymphocytes using GTX01466-10 CD8 alpha antibody [OKT8] (PE-Cy7). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.25 microg (5 microl)
FACS analysis of human peripheral blood lymphocytes using GTX01466-10 CD8 alpha antibody [OKT8] (PE-Cy7). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.25 microg (5 microl)
FACS analysis of human peripheral blood lymphocytes using GTX01466-10 CD8 alpha antibody [OKT8] (PE-Cy7). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.25 microg (5 microl)

CD8 alpha antibody [OKT8] (PE-Cy7)

Research Use Only
GTX01466-10
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD8A
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD8 alpha antibody [OKT8] (PE-Cy7)
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: 0.25 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    OKT8
  • Concentration
    0.05 mg/ml
  • Conjugate
    Double Conjugated
  • Formulation
    Liquid
  • Gene ID925
  • Target name
    CD8A
  • Target description
    CD8a molecule
  • Target synonyms
    CD8; CD8 antigen, alpha polypeptide (p32); Leu2; Leu2 T-lymphocyte antigen; OKT8 T-cell antigen; p32; T cell co-receptor; T8 T-cell antigen; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP01732
  • Protein Name
    T-cell surface glycoprotein CD8 alpha chain
  • Scientific Description
    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Structural requirements for recognition of major histocompatibility complex class II by membrane-associated RING-CH (MARCH) protein E3 ligases. Jahnke M et al., 2012 Aug 17, J Biol Chem
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  • Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. Clement M et al., 2011 Jul 15, J Immunol
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  • A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Bagnara D et al., 2011 May 19, Blood
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  • DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. Lai AY et al., 2010 Aug 30, J Exp Med
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  • Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Teles RM et al., 2010 Nov, Infect Immun
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  • TCR complex-activated CD8 adhesion function by human T cells. Varghese JC et al., 2008 Nov 1, J Immunol
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  • Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D et al., 2008 Jun 1, J Immunol
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