ProductsBack/CD8 alpha antibody [OKT8] (PE)

FACS analysis of human peripheral blood lymphocytes using GTX01466-08 CD8 alpha antibody [OKT8] (PE). Solid lone : primary antibody Dashed line : isotype control antibody amount : 0.06 μg (5 μl)

CD8 alpha antibody [OKT8] (PE)

GTX01466-08

ApplicationsFlow Cytometry

Product group Antibodies

ReactivityHuman

TargetCD8A

Overview

Supplier
GeneTex
Product Name
CD8 alpha antibody [OKT8] (PE)
Delivery Days Customer
9
Application Supplier Note
FACS: 0.06 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
OKT8
Concentration
0.012 mg/ml
Conjugate
RPE
Gene ID925
Target name
CD8A
Target description
CD8 subunit alpha
Target synonyms
CD8, CD8alpha, IMD116, Leu2, p32, T-cell surface glycoprotein CD8 alpha chain, CD8 antigen, alpha polypeptide (p32), CD8a molecule, Leu2 T-lymphocyte antigen, OKT8 T-cell antigen, T cell co-receptor, T-cell antigen Leu2, T-lymphocyte differentiation antigen T8/Leu-2, T8 T-cell antigen
Host
Mouse
Isotype
IgG2a
Protein IDP01732
Protein Name
T-cell surface glycoprotein CD8 alpha chain
Scientific Description
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

References

Jahnke M, Trowsdale J, Kelly AP. Structural requirements for recognition of major histocompatibility complex class II by membrane-associated RING-CH (MARCH) protein E3 ligases. J Biol Chem. 2012,287(34):28779-89. doi: 10.1074/jbc.M112.381541
Read this paper
Clement M, Ladell K, Ekeruche-Makinde J, et al. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. J Immunol. 2011,187(2):654-63. doi: 10.4049/jimmunol.1003941
Read this paper
Bagnara D, Kaufman MS, Calissano C, et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease. Blood. 2011,117(20):5463-72. doi: 10.1182/blood-2010-12-324210
Read this paper
Lai AY, Fatemi M, Dhasarathy A, et al. DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med. 2010,207(9):1939-50. doi: 10.1084/jem.20100204
Read this paper
Teles RM, Krutzik SR, Ochoa MT, et al. Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 2010,78(11):4634-43. doi: 10.1128/IAI.00454-10
Read this paper
Varghese JC, Kane KP. TCR complex-activated CD8 adhesion function by human T cells. J Immunol. 2008,181(9):6002-9.
Read this paper
Thakral D, Dobbins J, Devine L, et al. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008,180(11):7431-42.
Read this paper

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CD8 alpha antibody [OKT8] (PE)

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