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ProductsBack/CD86 antibody [BU63]

CD86 antibody [BU63]

GTX74650
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman
TargetCD86
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD86 antibody [BU63]
  • Delivery Days Customer
    9
  • Application Supplier Note
    IHC-Fr: 1/20-1/100. FACS: 1/20-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    BU63
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID942
  • Target name
    CD86
  • Target description
    CD86 molecule
  • Target synonyms
    B7-2, B7.2, B70, CD28LG2, LAB72, T-lymphocyte activation antigen CD86, B-lymphocyte activation antigen B7-2, BU63, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CD86 v6, CTLA-4 counter-receptor B7.2, FUN-1
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP42081
  • Protein Name
    T-lymphocyte activation antigen CD86
  • Scientific Description
    This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Manferdini C, Saleh Y, Dolzani P, et al. Impact of Isolation Procedures on the Development of a Preclinical Synovial Fibroblasts/Macrophages in an In Vitro Model of Osteoarthritis. Biology (Basel). 2020,9(12). doi: 10.3390/biology9120459
    Read this paper
  • Tsai PY, Chen KR, Li YC, et al. NLRP7 Is Involved in the Differentiation of the Decidual Macrophages. Int J Mol Sci. 2019,20(23). doi: 10.3390/ijms20235994
    Read this paper
  • Carbone F, Rigamonti F, Burger F, et al. Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis. Int J Cardiol. 2018,255:195-199. doi: 10.1016/j.ijcard.2018.01.008
    Read this paper
  • Wang LT, Chiou SS, Chai CY, et al. Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression. Cancer Res. 2017,77(15):4065-4077. doi: 10.1158/0008-5472.CAN-17-0090
    Read this paper
  • McCarthy NE, Bashir Z, Vossenkämper A, et al. Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol. 2013,191(5):2752-63. doi: 10.4049/jimmunol.1202959
    Read this paper
  • Silk KM, Leishman AJ, Nishimoto KP, et al. Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype. J Biomed Biotechnol. 2012,2012:172420. doi: 10.1155/2012/172420
    Read this paper
  • Hovden AO, Karlsen M, Jonsson R, et al. Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 2011,12:2. doi: 10.1186/1471-2172-12-2
    Read this paper
  • Salte T, Pathak S, Wentzel-Larsen T, et al. Increased intracellular growth of Mycobacterium avium in HIV-1 exposed monocyte-derived dendritic cells. Microbes Infect. 2011,13(3):276-83. doi: 10.1016/j.micinf.2010.11.001
    Read this paper
  • Goodyear O, Agathanggelou A, Novitzky-Basso I, et al. Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood. 2010,116(11):1908-18. doi: 10.1182/blood-2009-11-249474
    Read this paper
  • Adler HS, Simon A, Graulich E, et al. Neuronal nitric oxide synthase modulates maturation of human dendritic cells. J Immunol. 2010,184(11):6025-34. doi: 10.4049/jimmunol.0901327
    Read this paper

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