CDK4 antibody
GTX102993
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetCDK4
Overview
- SupplierGeneTex
- Product NameCDK4 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.82 mg/ml
- ConjugateUnconjugated
- Gene ID1019
- Target nameCDK4
- Target descriptioncyclin dependent kinase 4
- Target synonymsCMM3, PSK-J3, cyclin-dependent kinase 4, cell division protein kinase 4
- HostRabbit
- IsotypeIgG
- Protein IDP11802
- Protein NameCyclin-dependent kinase 4
- Scientific DescriptionThe protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq]
- ReactivityBovine, Human, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Cardile A, Zanrè V, Campagnari R, et al. Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-κB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism. Int J Mol Sci. 2023,24(2). doi: 10.3390/ijms24021263Read this paper
- Chen CY, Li YH, Liao WL, et al. Antrodia salmonea Extracts Regulate p53-AR Signaling and Apoptosis in Human Prostate Cancer LNCaP Cells. Evid Based Complement Alternat Med. 2022,2022:7033127. doi: 10.1155/2022/7033127Read this paper
- Yang Q, Ma X, Xiao Y, et al. Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity. Acta Pharm Sin B. 2022,12(7):3139-3155. doi: 10.1016/j.apsb.2022.02.024Read this paper
- Chen SY, Chao CN, Huang HY, et al. Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin. Oncol Lett. 2022,23(2):61. doi: 10.3892/ol.2021.13179Read this paper
- Navarro-Guerrero E, Tay C, Whalley JP, et al. Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Sci Rep. 2021,11(1):4245. doi: 10.1038/s41598-021-82137-zRead this paper
- Huang HY, Chou HC, Law CH, et al. Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. J Cell Mol Med. 2020,24(17):9737-9751. doi: 10.1111/jcmm.15535Read this paper
- Huang CW, Chang YH, Lee HH, et al. Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma. FASEB J. 2020,34(7):9678-9693. doi: 10.1096/fj.202000573RRRead this paper
- Yeh HT, Tsai YS, Chen MS, et al. Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. Eur J Pharmacol. 2019,863:172658. doi: 10.1016/j.ejphar.2019.172658Read this paper
- Chen SY, Huang HY, Lin HP, et al. Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway. Int J Mol Med. 2019,44(5):1687-1696. doi: 10.3892/ijmm.2019.4324Read this paper
- Fararjeh AS, Chen LC, Ho YS, et al. Proteasome 26S Subunit, non-ATPase 3 (PSMD3) Regulates Breast Cancer by Stabilizing HER2 from Degradation. Cancers (Basel). 2019,11(4). doi: 10.3390/cancers11040527Read this paper
Datasheet
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