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CDK4 antibody

Name: CDK4 antibody
SKU: GTX102993_G10
Availability: BackOrder

GTX102993

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

DownloadDatasheet

Product group Antibodies

TargetCDK4

Overview

Supplier
GeneTex
Product Name
CDK4 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.82 mg/ml
Conjugate
Unconjugated
Gene ID1019
Target name
CDK4
Target description
cyclin dependent kinase 4
Target synonyms
cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; PSK-J3
Host
Rabbit
Isotype
IgG
Protein IDP11802
Protein Name
Cyclin-dependent kinase 4
Scientific Description
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-kappaB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
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Antrodia salmonea Extracts Regulate p53-AR Signaling and Apoptosis in Human Prostate Cancer LNCaP Cells.
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Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity.
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Auranofin induces urothelial carcinoma cell death via reactive oxygen species production and synergy with cisplatin. Chen SY et al., 2022 Feb, Oncol Lett
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Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Navarro-Guerrero E et al., 2021 Feb 19, Sci Rep
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Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis. Huang HY et al., 2020 Sep, J Cell Mol Med
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Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma. Huang CW et al., 2020 Jul, FASEB J
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Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. Yeh HT et al., 2019 Nov 15, Eur J Pharmacol
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Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway. Chen SY et al., 2019 Nov, Int J Mol Med
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Proteasome 26S Subunit, non-ATPase 3 (PSMD3) Regulates Breast Cancer by Stabilizing HER2 from Degradation. Fararjeh AS et al., 2019 Apr 12, Cancers (Basel)
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CDK4 antibody

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Overview

References

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