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ProductsBack/CDK4 (phospho Thr172) antibody - Orthogonal Validated
WB analysis of NIH/3T3 cells treated by Hydroxyurea (4 mM) at 37oC for 20 hours using GTX00778 CDK4 (phospho Thr172) antibody. Dilution : 1:1000 Loading : 25microg per lane
WB analysis of NIH/3T3 cells treated by Hydroxyurea (4 mM) at 37oC for 20 hours using GTX00778 CDK4 (phospho Thr172) antibody. Dilution : 1:1000 Loading : 25microg per lane
WB analysis of NIH/3T3 cells treated by Hydroxyurea (4 mM) at 37oC for 20 hours using GTX00778 CDK4 (phospho Thr172) antibody. Dilution : 1:1000 Loading : 25microg per lane

CDK4 (phospho Thr172) antibody - Orthogonal Validated

Research Use Only
GTX00778
GeneTex
ApplicationsWestern Blot
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetCDK4
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Overview

  • Supplier
    GeneTex
  • Product Name
    CDK4 (phospho Thr172) antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID1019
  • Target name
    CDK4
  • Target description
    cyclin dependent kinase 4
  • Target synonyms
    cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; PSK-J3
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. Chen BR et al., 2021 Sep 3, Elife
    Read more
  • CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression. Fu H et al., 2021 Jan, Mol Med Rep
    Read more