CDK8 antibody

GeneTex

CDK8 antibody

9

Immunofluorescence: assay dependent. Immunoprecipitation (with protein A, native): use at a concentration of 10microg / mg of lysate. Western Blotting: use at a concentration of 1 - 2microg / ml for 2hrs at RT. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of 54 kDa, which corresponds to the predicted molecular weight of Cdk 8.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

CDK8

cyclin dependent kinase 8

CDK8 protein kinase; cell division protein kinase 8; cyclin-dependent kinase 8; IDDHBA; K35; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; protein kinase K35

Rabbit

IgG

Cyclin-dependent kinase 8

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Human, Mouse, Rat

2°C to 8°C

12352203