Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CDKN2AIP Polyclonal Antibody at dilution 1:40
CDKN2AIP Polyclonal Antibody

E-AB-10510
Product group Antibodies
Overview
- SupplierElabscience
- Product NameCDKN2AIP Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration0.3mg/ml
- Scientific DescriptionCDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
- UNSPSC12352203