CENPE antibody [1H12]

GeneTex

CENPE antibody [1H12]

9

Human CENP-E. Not tested on reactivity with rodents or other vertebrates

Recommended Starting Dilutions:For ICC/IF: Use at 0.5-1microg/mlFor IP: Use approximately 3microg/ml of antibody for 300microg of cell lysateOptimal dilutions should be determined experimentally by the researcher.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

1H12

Unconjugated

CENPE

centromere protein E

CENP-E; Centromere autoantigen E (312kD); centromere protein E, 312kDa; centromere-associated protein E; KIF10; kinesin family member 10; kinesin-7; kinesin-related protein CENPE; MCPH13; PPP1R61; protein phosphatase 1, regulatory subunit 61

Mouse

IgG1

CENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase. In contrast to other centromere proteins, CENPE is not detected at centromeres during interphase, and first appears at the centromere region of chromosomes during prometaphase. CENPE function is required for the transition from metaphase to anaphase. CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation.

Human

-20°C or -80°C,2°C to 8°C

12352203