Cevidoplenib

MedChem Express

Cevidoplenib [1703788-21-9]

10

1703788-21-9

Research Use Only

99.58

C25H27N7O3

473.53

Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk) , with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC 50 s of 6.2 nM (Syk), 1.859 microM (Jak2), 5.807 microM (Jak3), 0.412 microM (RET), 0.687 microM (KOR), 1.783 microM (FLT3), 16.96 microM (FGFR1), 5.662 microM (FGFR3), and 0.709 microM (Pyk2), respectively [1] [2] [3] .

O=C(C1CC1)C2=CN(C)C3=C2C=C(NC4=NC=CC(N5N=C(C)C(CN6OC[C@@H](O)C6)=C5)=N4)C=C3

-20°C,2°C to 8°C

12352200