Cevidoplenib

Biorbyt

Cevidoplenib [1703788-21-9]

10

1703788-21-9

Research Use Only

C25H27N7O3

473.5269845

Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 microM (Jak2), 5.807 microM (Jak3), 0.412 microM (RET), 0.687 microM (KOR), 1.783 microM (FLT3), 16.96 microM (FGFR1), 5.662 microM (FGFR3), and 0.709 microM (Pyk2), respectively.

O=C(C1=CN(C)C2C=CC(=CC1=2)NC1N=CC=C(N=1)N1C=C(C(C)=N1)CN1C[C@@H](CO1)O)C1CC1

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