BX-795

Selleck Chemicals

BX-795 [702675-74-9]

9

702675-74-9

...

BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3beta more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKepsilon with IC 50 values of 6 nM and 41 nM, respectively.

-80°C

51202000