CHMFL-PI3KD-317 [2244992-76-3]

MedChem Express

CHMFL-PI3KD-317 [2244992-76-3]

10

2244992-76-3

Research Use Only

98.04

C21H24ClN5O3S2

494.03

CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kdelta inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kalpha (IC50, 62.6 nM), PI3Kbeta (IC50, 284 nM), PI3Kgamma (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kdelta-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells[1].

ClC1=C(NS(=O)(C2=CC(C)=CC=C2)=O)C=C(C3=C(C)N=C(NC([C@H](C(C)C)N)=O)S3)C=N1

-20°C

12352200