CHMFL-PI3KD-317 [2244992-76-3]

TargetMol Chemicals

CHMFL-PI3KD-317 [2244992-76-3]

9

2244992-76-3

Research Use Only

CHMFL-PI3KD-317

0.978

C21H24ClN5O3S2

494.03

CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kdelta inhibitor with an IC50 of 6 nM, exhibiting over 10-1500 fold selectivity over other class I, II, and III PIKK family isoforms, such as PI3Kalpha (IC50, 62.6 nM), PI3Kbeta (IC50, 284 nM), PI3Kgamma (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM), and PI4KIIIB (IC50, 300.2 nM). It inhibits PI3Kdelta-mediated Akt T308 phosphorylation in Raji cells with an EC50 of 4.3 nM and has antiproliferative effects on cancer cells.

3 years

CC(C)[C@H](N)C(=O)Nc1nc(C)c(s1)-c1cnc(Cl)c(NS(=O)(=O)c2cccc(C)c2)c1

-20°C

12352200