IHC image of CSB-PA878944LA01HU diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CHMP5 Antibody

CSB-PA878944LA01HU

ApplicationsImmunoFluorescence, ELISA, ImmunoHistoChemistry

Product group Antibodies

TargetCHMP5

Overview

Supplier
Cusabio
Product Name
CHMP5 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID51510
Target name
CHMP5
Target description
charged multivesicular body protein 5
Target synonyms
apoptosis-related protein PNAS-2; C9orf83; CGI-34; charged multivesicular body protein 5; chromatin-modifying protein 5; HSPC177; hVps60; PNAS-2; SNF7 domain containing 2; SNF7 domain-containing protein 2; SNF7DC2; vacuolar protein sorting-associated protein 60; Vps60
Host
Rabbit
Isotype
IgG
Protein IDQ9NZZ3
Protein Name
Charged multivesicular body protein 5
Scientific Description
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

CHMP5 Antibody

Large volume orders?

Overview

Related products