CISH Antibody

Cusabio

CISH Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

CISH

cytokine inducible SH2 containing protein

BACTS2, CIS, CIS-1, G18, SOCS, cytokine-inducible SH2-containing protein, cytokine-inducible inhibitor of signaling type 1B, suppressor of cytokine signaling

Rabbit

IgG

Cytokine-inducible SH2-containing protein

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Human

-20°C or -80°C

41116161