CITCO
ORB1089547
CAS Number338404-52-7
Product group Chemicals
Molecular Weight436.735
Overview
- SupplierBiorbyt
- Product NameCITCO [338404-52-7]
- Delivery Days Customer10
- CAS Number338404-52-7
- CertificationResearch Use Only
- Molecular FormulaC19H12Cl3N3OS
- Molecular Weight436.735
- Scientific DescriptionCITCO is a potent constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). CITCO altered expression of key drug-metabolizing enzymes and transporters in human hepatocytes, which positively affects the metabolic profile of CHOP. Coadministration of CITCO and CHOP in the coculture model led to significantly enhanced cytotoxicity in lymphoma cells but not in cardiomyocytes. Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss. The constitutive androstane receptor (CAR and NR1i3) is a key regulator of CYP2B6.
- SMILESClC1=CC=C(C=C1Cl)CO/N=C/C2=C(C3=CC=C(Cl)C=C3)N=C4SC=CN42
- UNSPSC12352200
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![CITCO [338404-52-7]](https://www.targetmol.com/group3/M00/02/83/CgoaEWY7L_-Ee-ymAAAAAA9FIo0460.png)
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