CLACP antibody
GTX70471
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCOL25A1
Overview
- SupplierGeneTex
- Product NameCLACP antibody
- Delivery Days Customer9
- Antibody SpecificityReacts with residues 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures an
- Application Supplier NoteWestern blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID84570
- Target nameCOL25A1
- Target descriptioncollagen type XXV alpha 1 chain
- Target synonymsalzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
- HostRabbit
- IsotypeIgG
- Protein IDQ9BXS0
- Protein NameCollagen alpha-1(XXV) chain
- Scientific DescriptionThis gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203