Bio-Connect

CLACP antibody

Research Use Only
GTX70471
GeneTex
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCOL25A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    CLACP antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    Reacts with residues 171-183 [NHGFLSADQQLIK] of the NC2-1 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures an
  • Application Supplier Note
    Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID84570
  • Target name
    COL25A1
  • Target description
    collagen type XXV alpha 1 chain
  • Target synonyms
    alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9BXS0
  • Protein Name
    Collagen alpha-1(XXV) chain
  • Scientific Description
    This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203