CLACP antibody

GeneTex

CLACP antibody

9

Reacts with residues 155-169 [KGEQGDQGPRMVFPK] of the NC2-2 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures

Western blot - Use at 1:500 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

COL25A1

collagen type XXV alpha 1 chain

alzheimer disease amyloid-associated protein; AMY; CFEOM5; CLAC; CLACP; CLAC-P; collagen alpha-1(XXV) chain; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component

Rabbit

IgG

Collagen alpha-1(XXV) chain

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Human

-20°C or -80°C,2°C to 8°C

12352203