CLEC4E Antibody, Biotin conjugated

Cusabio

CLEC4E Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

CLEC4E

C-type lectin domain family 4 member E

CLECSF9, MINCLE, C-type lectin domain family 4 member E, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9, C-type lectin superfamily member 9, macrophage-inducible C-type lectin

Rabbit

IgG

C-type lectin domain family 4 member E

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Human

-20°C or -80°C

41116161