CMPD101 [865608-11-3]

MedChem Express

CMPD101 [865608-11-3]

5

865608-11-3

Research Use Only

98.95

C24H21F3N6O

466.46

CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC50 of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCalpha with IC50s of 3.1 microM , 2.3 microM, 1.4 microM and 8.1 microM, respectively. CMPD101 can be used for the study of heart failure[1].

O=C(C1=CC(NCC2=NN=C(C3=CC=NC=C3)N2C)=CC=C1)NCC4=CC=CC=C4C(F)(F)F

-20°C,2°C to 8°C

12352200