CNTF antibody [AS23]

GeneTex

CNTF antibody [AS23]

9

ELISA: This antibody has been used as a coating antibody at 10 ug/ml in a two site ELISA with PS2-B. Typically the ELISA has a working range of 0-20000 pg/ml and a sensitivity of 10 pg/ml when used with biotin conjugated CNTF antibody. Recommended sample volumes are 25-200 microl. Recovery of hCNTF in human plasma is typically > 85 in the ELISA. IP: This antibody has been used to immunoprecipitate >90% hCNTF in solution using a double-antibody method. WB: Use at a concentration of 1 - 5 microg/ml. Predicted molecular weight: 24 kDa. Optimal dilutions/concentrations should be determined by the end user.

ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

AS23

1 mg/ml

Unconjugated

CNTF

ciliary neurotrophic factor

Ciliary Neuronotrophic Factor; ciliary neurotrophic factor; HCNTF

Mouse

IgG1

Ciliary neurotrophic factor

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203