Collinolactone

BioViotica

Collinolactone

10

Research Use Only

>98%

C21H28O5

360.45

Chemical. CAS: 2733581-46-7. Formula: C21H28O5. MW: 360.45. Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with Abeta-disaggregating activity. It showed dissociative effect on Abeta aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs (but not collinolactone) has shown inhibitory effects on a L929 cell line. - Collinolactone has neuroprotective and anti-neurodegenerative effects by reducing intracellular oxidative stress. It protects against glutamate-induced oxidative stress in a dose-dependent manner. Collinolactone is a potential anti-Alzheimer agent with Abeta-disaggregating activity. It showed dissociative effect on Abeta aggregates and tau tangles in vitro, with significantly reduced apoptosis and inflammation in neuronal and glial cells. In vivo studies on APP/PS1 double transgenic mice showed substantially dissociated hippocampal plaques. A set of semisynthetic collinolactone analogs (but not collinolactone) has shown inhibitory effects on a L929 cell line.

O=C1O[C@H](CC)C[C@]2([H])[C@]1([H])/C=C(C)\C=C\[C@](C[C@H](O)CC(O3)=O)([H])[C@]3([H])/C=C2\C

-20°C,2°C to 8°C

12352200