Curvularin [10140-70-2]

Name: Curvularin [10140-70-2]
SKU: AG-CN2-0147_A27
Availability: BackOrder

AG-CN2-0147

CAS Number10140-70-2

Product group Chemicals

Estimated Purity>95%

Molecular Weight292.3

Overview

Supplier
AdipoGen Life Sciences
Product Name
Curvularin
Delivery Days Customer
10
CAS Number
10140-70-2
Certification
Research Use Only
Estimated Purity
>95%
Molecular Formula
C16H20O5
Molecular Weight
292.3
Scientific Description
Antibiotic [1]. Antiprotozoal [1]. Antifungal and phytotoxic compound [1, 6]. Anti-inflammatory [7]. TGF-beta signaling inhibitor [8] Anticancer compound [2, 9]. Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII) [4, 5]. Cell division inhibitor [3]. Acetylcholinesterase (AChE) inhibitor [9]. - Chemical. CAS: 10140-70-2. Formula: C16H20O5. MW: 292.3. Isolated from Penicillium sp. FKI-1938 Antibiotic. Antiprotozoal. Antifungal and phytotoxic compound. Anti-inflammatory. TGF-beta signaling inhibitor Anticancer compound. Inhibits expression of inducible nitric oxide synthase (iNOS; NOSII). Cell division inhibitor. Acetylcholinesterase (AChE) inhibitor.
SMILES
C[C@H]1CCCCCC(=O)C2=C(O)C=C(O)C=C2CC(=O)O1
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

Antimicrobial properties of fungal macrolide antibiotics: V. Betina & D. Micekova; Z. Allg. Mikrobiol. 12, 355 (1972)
Curvularin from Penicillium baradicum Baghdadi NRRL 3754, and biological effects: R.F. Vesonder, et al.; J. Environ. Sci. Health 11, 289 (1976)
Structural study of curvularin, a cell division inhibitor: E.L. Ghisalberti, et al.; Austral. J. Chem. 46, 571 (1993)
Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi: Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003)
Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues: S. Elzner, et al.; ChemMedChem 3, 924 (2008)
Isolation and Difference in Anti-Staphylococcus aureus Bioactivity of Curvularin Derivates from Fungus Eupenicillium sp.: L.W. Xie, et al.; Appl. Biochem. Biotechnol. 159, 284 (2009)
The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis: N. Schmidt, et al.; J. Pharmacol. Exp. Ther. 343, 106 (2012)
Inhibition of TGF-beta signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone: K. Rudolph, et al.; Cytokine 61, 285 (2013)
Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India: C.G. Kumar, et al.; SpringerPlus 2, 122 (2013)