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Combretastatin A-1 phosphate (tetrasodium) [288847-34-7]

HY-16146
MedChem Express
CAS Number288847-34-7
Product group Chemicals
Molecular Weight580.23
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Combretastatin A-1 phosphate (tetrasodium) [288847-34-7]
  • Delivery Days Customer
    10
  • CAS Number
    288847-34-7
  • Certification
    Research Use Only
  • Molecular Formula
    C18H18Na4O12P2
  • Molecular Weight
    580.23
  • Scientific Description
    Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a proagent of Combretastatin A-1, is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 phosphate tetrasodium inhibits the Wnt/beta-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 phosphate tetrasodium exhibits anti-tumor and anti-vascular effects[1][2][3].
  • SMILES
    O=P(O[Na])(O[Na])OC1=C(C(OC)=CC=C1/C=C\C2=CC(OC)=C(C(OC)=C2)OC)OP(O[Na])(O[Na])=O
  • UNSPSC
    12352200