Complement C4d(TDM16), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Complement C4d(TDM16), CF405S conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

TDM16

0.1 mg/ml

Other Conjugate

C4A

complement C4A (Rodgers blood group)

acidic C4; acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4; C4A anaphylatoxin; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; complement C4-A; complement component 4A (Rodgers blood group); CPAMD2; MHC class III region complement; RG; Rodgers form of C4

Mouse

IgG1

Complement C4-B

This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203