Copanlisib (dihydrochloride)

MedChem Express

Copanlisib (dihydrochloride) [1402152-13-9]

9

1402152-13-9

Research Use Only

99.55

C23H30Cl2N8O4

553.44

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC 50 s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kalpha , PI3Kdelta , PI3Kbeta and PI3Kgamma , respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity [1] .

O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25.[H]Cl.[H]Cl

2°C to 8°C

12352200