Cot inhibitor-2

MedChem Express

Cot inhibitor-2 [915363-56-3]

10

915363-56-3

Research Use Only

99.22

C26H25Cl2FN8

539.43

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-alpha production in LPS-stimulated human whole blood with an IC50 of 0.3 microM[1].

N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

-20°C,2°C to 8°C

12352200