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Cot inhibitor-2

Research Use Only
T10866
TargetMol Chemicals
CAS Number915363-56-3
Product group Chemicals
Molecular Weight539.43
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Cot inhibitor-2
  • Delivery Days Customer
    4
  • CAS Number
    915363-56-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Cot inhibitor-2
  • Molecular Formula
    C26H25Cl2FN8
  • Molecular Weight
    539.43
  • Scientific Description
    Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-alfa production in human whole blood with an IC50 of 0.3 uM.
  • Shelf life instruction
    3 years
  • SMILES
    N(C=1C2=C(C(Cl)=CC(NCC3=CN(N=N3)C4CCN(CC)CC4)=C2)N=CC1C#N)C5=CC(Cl)=C(F)C=C5
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Wu J, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 ; 19(13):3485-3488.
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