CPI-455 (hydrochloride) [2095432-28-1]

MedChem Express

CPI-455 (hydrochloride) [2095432-28-1]

10

2095432-28-1

Research Use Only

99.95

h302, h315, h319, h335

C16H15ClN4O

314.77

CPI-455 hydrochloride is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 hydrochloride mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1].

N#CC1=C2NC(C3=CC=CC=C3)=C(C(C)C)C(N2N=C1)=O.[H]Cl

2°C to 8°C

12352200