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CPT1A antibody [C1C2], Internal

GTX114337
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetCPT1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    CPT1A antibody [C1C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1374
  • Target name
    CPT1A
  • Target description
    carnitine palmitoyltransferase 1A
  • Target synonyms
    CPT I, CPT1, CPT1-L, CPTI-L, L-CPT1, carnitine O-palmitoyltransferase 1, liver isoform, carnitine palmitoyltransferase 1A (liver), carnitine palmitoyltransferase I, liver, succinyltransferase CPT1A
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP50416
  • Protein Name
    Carnitine O-palmitoyltransferase 1, liver isoform
  • Scientific Description
    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Ngo J, Choi DW, Stanley IA, et al. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023,42(11):e111901. doi: 10.15252/embj.2022111901
    Read this paper
  • Zhu Z, Zhou W, Yang Y, et al. Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease. Evid Based Complement Alternat Med. 2021,2021:9931542. doi: 10.1155/2021/9931542
    Read this paper
  • Ezzeddini R, Taghikhani M, Salek Farrokhi A, et al. Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance. J Physiol Biochem. 2021,77(2):249-260. doi: 10.1007/s13105-021-00791-3
    Read this paper
  • Chang TC, Chiou WC, Lai WH, et al. Ugonin J improves metabolic disorder and ameliorates nonalcoholic fatty liver disease by regulating the AMPK/AKT signaling pathway. Pharmacol Res. 2021,163:105298. doi: 10.1016/j.phrs.2020.105298
    Read this paper
  • Tsai YT, Ruan JW, Chang CS, et al. Antrodia cinnamomea Confers Obesity Resistance and Restores Intestinal Barrier Integrity in Leptin-deficient Obese Mice. Nutrients. 2020,12(3). doi: 10.3390/nu12030726
    Read this paper
  • Chang TC, Chiang H, Lai YH, et al. Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. BMC Complement Altern Med. 2019,19(1):368. doi: 10.1186/s12906-019-2782-3
    Read this paper
  • You BJ, Hour MJ, Chen LY, et al. Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. Sci Rep. 2019,9(1):3306. doi: 10.1038/s41598-019-39778-y
    Read this paper
  • You BJ, Chen LY, Hsu PH, et al. Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. Chem Res Toxicol. 2019,32(2):255-264. doi: 10.1021/acs.chemrestox.8b00269
    Read this paper
  • Tarling EJ, Ahn H, de Aguiar Vallim TQ. The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 2015,35(4):787-95. doi: 10.1161/ATVBAHA.114.304179
    Read this paper
  • Roy D, Mondal S, Wang C, et al. Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014,2:13. doi: 10.1186/2049-3002-2-13
    Read this paper