Bio-Connect

CPT1A antibody [C1C2], Internal

GTX114337
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetCPT1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    CPT1A antibody [C1C2], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1374
  • Target name
    CPT1A
  • Target description
    carnitine palmitoyltransferase 1A
  • Target synonyms
    carnitine O-palmitoyltransferase 1, liver isoform; carnitine palmitoyltransferase 1A (liver); carnitine palmitoyltransferase I, liver; CPT I; CPT1; CPT1-L; CPTI-L; L-CPT1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP50416
  • Protein Name
    Carnitine O-palmitoyltransferase 1, liver isoform
  • Scientific Description
    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.
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  • Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease. Zhu Z et al., 2021, Evid Based Complement Alternat Med
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  • Downregulation of fatty acid oxidation by involvement of HIF-1alpha and PPARgamma in human gastric adenocarcinoma and related clinical significance. Ezzeddini R et al., 2021 May, J Physiol Biochem
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  • Ugonin J improves metabolic disorder and ameliorates nonalcoholic fatty liver disease by regulating the AMPK/AKT signaling pathway. Chang TC et al., 2021 Jan, Pharmacol Res
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  • Antrodia cinnamomea Confers Obesity Resistance and Restores Intestinal Barrier Integrity in Leptin-deficient Obese Mice. Tsai YT et al., 2020 Mar 10, Nutrients
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  • Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice. Chang TC et al., 2019 Dec 13, BMC Complement Altern Med
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  • Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. You BJ et al., 2019 Mar 1, Sci Rep
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  • Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. You BJ et al., 2019 Feb 18, Chem Res Toxicol
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  • The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Tarling EJ et al., 2015 Apr, Arterioscler Thromb Vasc Biol
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  • Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Roy D et al., 2014, Cancer Metab
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