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CRACR2A Polyclonal Antibody

RD219269A
Reddot Biotech
TargetCRACR2A
Product group Antibodies
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    CRACR2A Polyclonal Antibody
  • Delivery Days Customer
    5
  • Concentration
    0.84 mg/ml
  • Gene ID84766
  • Target name
    CRACR2A
  • Target description
    calcium release activated channel regulator 2A
  • Target synonyms
    Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EFCAB4B; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; RAB46; ras-related protein Rab-46
  • Scientific Description
    Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203