EFCAB4B antibody

GeneTex

EFCAB4B antibody

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.56 mg/ml

Unconjugated

CRACR2A

calcium release activated channel regulator 2A

Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EFCAB4B; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; RAB46; ras-related protein Rab-46

Rabbit

IgG

EF-hand calcium-binding domain-containing protein 4B

Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Human

-20°C or -80°C,2°C to 8°C

12352203