CRACR2A Polyclonal Antibody

Reddot Biotech

CRACR2A Polyclonal Antibody

5

Western Blot, ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

CRACR2A

calcium release activated channel regulator 2A

Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A; calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; CRAC regulator 2A; EFCAB4B; EF-hand calcium binding domain 4B; EF-hand calcium-binding domain-containing protein 4B; RAB46; ras-related protein Rab-46

Rabbit

IgG

Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Human, Mouse, Rat

-20°C

12352203