CRT0044876

MedChem Express

CRT0044876 [6960-45-8]

9

6960-45-8

Research Use Only

98.88

C9H6N2O4

206.157

CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor ( IC 50 =~3 microM). CRT0044876 inhibits the AP endonuclease, 3-phosphodiesterase and 3-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds [1] .

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)O

-20°C,2°C to 8°C

12352200