CtIP antibody [19E8]
GTX70264
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, Other Application
Product group Antibodies
ReactivityHuman, Mouse
TargetRBBP8
Overview
- SupplierGeneTex
- Product NameCtIP antibody [19E8]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:1000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID19E8
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID5932
- Target nameRBBP8
- Target descriptionRB binding protein 8, endonuclease
- Target synonymsCOM1; CTBP-interacting protein; CTIP; DNA endonuclease RBBP8; JWDS; RBBP-8; retinoblastoma binding protein 8; RIM; SAE2; SCKL2; sporulation in the absence of SPO11 protein 2 homolog
- HostMouse
- IsotypeIgG1
- Protein IDQ99708
- Protein NameDNA endonuclease RBBP8
- Scientific DescriptionThe protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myeloma. Liu M et al., 2022, Int J Biol SciRead more
- A role for human homologous recombination factors in suppressing microhomology-mediated end joining. Ahrabi S et al., 2016 Jul 8, Nucleic Acids ResRead more
- Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Baude A et al., 2016 Mar 18, Nucleic Acids ResRead more
- RB E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. Liao CC et al., 2010 Oct 22, J Biol ChemRead more
- Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Gu B et al., 2009 May 1, Cell CycleRead more
- CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Wu M et al., 2007 Dec, Mol Cancer ResRead more
- CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Liu F et al., 2006 Apr, Mol Cell BiolRead more