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CTPI-2 [68003-38-3]

CTPI-2 [68003-38-3]

T8732
TargetMol Chemicals
CAS Number68003-38-3
DownloadMSDS
Product group Chemicals
Estimated Purity97.23%
Molecular Weight356.74
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    CTPI-2 [68003-38-3]
  • Delivery Days Customer
    4
  • CAS Number
    68003-38-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    CTPI-2
  • Estimated Purity
    97.23%
  • Molecular Formula
    C13H9ClN2O6S
  • Molecular Weight
    356.74
  • Scientific Description
    CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 microM). CTPI-2 inhibits glycolysis, PPARgamma, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet.
  • Shelf life instruction
    3 years
  • SMILES
    OC(=O)c1ccccc1NS(=O)(=O)c1ccc(Cl)c(c1)[N+]([O-])=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Tan M et al., 2020 Jul, Cell Death Differ
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