CXCR2-IN-2

MedChem Express

CXCR2-IN-2 [1838123-21-9]

10

1838123-21-9

Research Use Only

99.52

C18H23ClN2O5S

414.90

CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist ( IC 50 =5.2 nM/1 nM in beta-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-alpha induced CD11b expression with an IC 50 of 0.04 microM [1] .

O=C(N[C@H]1C(C)=CCC1)NC2=CC=C(Cl)C(S(=O)([C@]3(C)COCC3)=O)=C2O

-20°C,2°C to 8°C

12352200