CXCR2-IN-2 [1838123-21-9]

TargetMol Chemicals

CXCR2-IN-2 [1838123-21-9]

86

1838123-21-9

Research Use Only

CXCR2-IN-2

C18H23ClN2O5S

414.9

CXCR2-IN-2 is a selective CXCR2 antagonist that is brain penetrant and orally bioavailable, with IC50 values of 5.2 nM and 1 nM in the beta-arrestin assay and CXCR2 Tango assay, respectively. It exhibits approximately 730-fold selectivity over CXCR1 and greater than 1900-fold selectivity over all other chemokine receptors. Furthermore, CXCR2-IN-2 effectively inhibits Gro-alpha induced CD11b expression in human whole blood, displaying an IC50 of 0.04 microM[1].

3 years

CC1=CCC[C@H]1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@@]1(C)CCOC1

-20°C

51202000