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WB analysis of human CYP1A1 (AA: 203-461) recombinant protein using GTX60543 CYP1A1 antibody [6G5].
WB analysis of human CYP1A1 (AA: 203-461) recombinant protein using GTX60543 CYP1A1 antibody [6G5].
WB analysis of human CYP1A1 (AA: 203-461) recombinant protein using GTX60543 CYP1A1 antibody [6G5].

CYP1A1 antibody [6G5]

GTX60543
GeneTex
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCYP1A1
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Overview

  • Supplier
    GeneTex
  • Product Name
    CYP1A1 antibody [6G5]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1/500 - 1/2000. IHC-P: 1/200 - 1/1000. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    6G5
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1543
  • Target name
    CYP1A1
  • Target description
    cytochrome P450 family 1 subfamily A member 1
  • Target synonyms
    AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, cytochrome P450 1A1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, hydroperoxy icosatetraenoate dehydratase, xenobiotic monooxygenase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP04798
  • Protein Name
    Cytochrome P450 1A1
  • Scientific Description
    This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzymes endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wei KL, Gao GL, Chou YT, et al. Sorafenib is an antagonist of the aryl hydrocarbon receptor. Toxicology. 2022,470:153118. doi: 10.1016/j.tox.2022.153118
    Read this paper
  • Vázquez-Gómez G, Rocha-Zavaleta L, Rodríguez-Sosa M, et al. Benzo[a]pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells. Toxicol Lett. 2018,289:54-62. doi: 10.1016/j.toxlet.2018.03.012
    Read this paper