CYP3cide

MedChem Express

CYP3cide [1390637-82-7]

10

1390637-82-7

Research Use Only

99.92

C26H32N8

456.59

CYP3cide (PF-4981517) is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) . The IC 50 values for Midazolam 1-hydroxylase activity are 0.03 microM, 17 microM, and 71 microM for CYP3A4 , CYP3A5, and CYP3A7, respectively. CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on agent metabolism [1] .

CC1=CC=C(C2=C(C3=NN(C)C4=NC=NC(N5C[C@@H](N6CCCCC6)CC5)=C43)C=NN2C)C=C1

-20°C

12352200