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Cytochrome C (Mitochondrial Marker)(6H2.B4), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC040184
Biotium
ApplicationsFlow Cytometry, ImmunoFluorescence
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetCYCS
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Overview

  • Supplier
    Biotium
  • Product Name
    Cytochrome C (Mitochondrial Marker)(6H2.B4), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoFluorescence
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    6H2.B4
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID54205
  • Target name
    CYCS
  • Target description
    cytochrome c, somatic
  • Target synonyms
    CYC; cytochrome c; HCS; THC4
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP99999
  • Protein Name
    Cytochrome c
  • Scientific Description
    Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203