Cytostatin (sodium salt)

Biorbyt

Cytostatin (sodium salt) [457070-06-3]

10

457070-06-3

Research Use Only

98.00%

C21H33NaO7P

451.452

Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 microg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 microg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

[Na].[H][C@]1(OC(=O)C=C[C@@H]1C)[C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)\C=C/C=C\C=C\C - c:5 -

-20°C

12352200