D-I03

MedChem Express

D-I03 [688342-78-1]

10

688342-78-1

Research Use Only

99.70

C23H36N6S

428.64

D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 microM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 microM and 8 microM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin[1][2].

S=C(NC1=CC=C2N=C(N3CCN(CC)CC3)C=C(C)C2=C1)NCCN(CC)CC

-20°C,2°C to 8°C

12352200