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DAP3 antibody [N1C2-2]

GTX113864
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetDAP3
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Overview

  • Supplier
    GeneTex
  • Product Name
    DAP3 antibody [N1C2-2]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7818
  • Target name
    DAP3
  • Target description
    death associated protein 3
  • Target synonyms
    DAP-3, MRP-S29, MRPS29, PRLTS7, S29mt, bMRP-10, mS29, small ribosomal subunit protein mS29, 28S ribosomal protein S29, mitochondrial, ionizing radiation resistance conferring protein, mitochondrial 28S ribosomal protein S29, mitochondrial small ribosomal subunit protein mS29
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP51398
  • Protein Name
    Small ribosomal subunit protein mS29
  • Scientific Description
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5 UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Min S, Lee YK, Hong J, et al. MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness. Cell Death Dis. 2021,12(11):1076. doi: 10.1038/s41419-021-04370-8
    Read this paper
  • Lee YK, Lim JJ, Jeoun UW, et al. Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness. J Biol Chem. 2017,292(49):20208-20217. doi: 10.1074/jbc.M117.809012
    Read this paper